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面部和颈部非结核分枝杆菌感染——实际考量

Nontuberculous mycobacterial infections of the face and neck--practical considerations.

作者信息

Olson N R

出版信息

Laryngoscope. 1981 Oct;91(10):1714-26. doi: 10.1288/00005537-198110000-00018.

Abstract

Cervicofacial nontuberculous mycobacterial (NTM) infections are a diagnostic and therapeutic dilemma which may be encountered by the Otolaryngologist. A review of the world's literature indicates that these infections are being diagnosed more frequently and that they far outnumber cervical infections by Mycobacterium tuberculosis. The organisms are ubiquitous. The portal of entry may be through a small defect in the skin or mucosa. They rarely, if ever, cause serious systemic illness. Diagnosis is by culture of the organism, however, cultures are usually not available at the time the patient is treated. Treatment, then, must be based on the results of skin tests, examination of pus and tissue, a "typical clinical presentation," and elimination of other diseases. The differential diagnosis is extensive. This review reports 21 patients with proven or suspected NTM infections of the face and neck. Eight of these patients were treated by traditional methods utilizing completed excision and, in some cases, drug therapy. Eleven were treated by curettage alone, and two more by curettage and drugs. The results were excellent by all of these forms of treatment. These findings support the proposition that curettage is a simple, safe, and effective method of treatmenting cervicofacial NTM infections and should be utilized as the primary treatment in all suspected or proven cases of this disease. The method dose not exclude other forms of treatment being utilized if they should be required.

摘要

头颈部非结核分枝杆菌(NTM)感染是耳鼻喉科医生可能会遇到的诊断和治疗难题。对世界文献的回顾表明,这些感染的诊断越来越频繁,而且其数量远远超过结核分枝杆菌引起的颈部感染。这些微生物无处不在。感染途径可能是通过皮肤或黏膜的小破损处。它们极少会引发严重的全身性疾病。诊断依靠微生物培养,但在治疗患者时通常无法获得培养结果。因此,治疗必须基于皮肤试验结果、脓液和组织检查、“典型临床表现”以及排除其他疾病。鉴别诊断范围广泛。本综述报告了21例经证实或疑似面部和颈部NTM感染的患者。其中8例患者采用传统方法治疗,即完整切除,有些情况下还结合药物治疗。11例仅接受刮除术治疗,另外2例接受刮除术和药物治疗。所有这些治疗方式的效果都很好。这些发现支持这样一种观点,即刮除术是治疗头颈部NTM感染的一种简单、安全且有效的方法,应作为所有疑似或确诊该疾病病例的主要治疗方法。如果需要,该方法并不排除使用其他治疗方式。

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