Tikkanen I, Törnroth T, Miettinen A, Fyhrquist F
Nephron. 1981;28(2):90-5. doi: 10.1159/000182122.
In order to explore the impact of nephritis on the development of hypertension, rats with Heymann nephritis were given 0.9% NaCl to drink, in combination with or without DOCA injections, for up to 6 months. Combined nephritis-DOCA-NaCl resulted in severe hypertension and shortened life span, whereas nephritis-NaCl combination failed to induce hypertension or shorten life span. All immunized rats developed membranous glomerulonephritis but creatinine clearance did not decrease. DOCA-NaCl-treated nephritic rats had a heavier proteinuria and more marked renal lesions than NaCl-treated nephritis rats. Proliferative-sclerotic glomerular lesions were seen in the nephritis-DOCA-NaCl group only, correlating to the severity of hypertension. Other renal and extrarenal vascular lesions, increasing with time, also appeared related to the severity of hypertension. This suggests a secondary relationship of vascular damage to hypertension in this model. Appearance of proteinuria preceded the establishment of hypertension, suggesting that nephritis sensitized to the development of hypertension during DOCA-NaCl treatment. Sodium excess alone, however, did not induce hypertension in Heymann nephritic rats. The present Heymann nephritis-DOCA-NaCl hypertension model appears a useful model for the study of hypertension complicating glomerulonephritis.
为了探究肾炎对高血压发展的影响，给患海曼肾炎的大鼠饮用0.9%氯化钠溶液，并结合或不结合去氧皮质酮（DOCA）注射，持续6个月。肾炎-DOCA-氯化钠联合作用导致严重高血压并缩短寿命，而肾炎-氯化钠组合未能诱发高血压或缩短寿命。所有免疫大鼠均发展为膜性肾小球肾炎，但肌酐清除率并未降低。与用氯化钠处理的肾炎大鼠相比，用DOCA-氯化钠处理的肾炎大鼠蛋白尿更严重，肾脏病变更明显。仅在肾炎-DOCA-氯化钠组中观察到增殖性硬化性肾小球病变，这与高血压的严重程度相关。随着时间推移出现的其他肾脏和肾外血管病变，似乎也与高血压的严重程度有关。这表明在该模型中血管损伤与高血压之间存在继发性关系。蛋白尿的出现先于高血压的形成，这表明肾炎使大鼠在DOCA-氯化钠治疗期间对高血压的发展敏感。然而，单纯的钠过量并未在海曼肾炎大鼠中诱发高血压。目前的海曼肾炎-DOCA-氯化钠高血压模型似乎是研究肾小球肾炎并发高血压的有用模型。
