Tikkanen I
Acta Pathol Microbiol Scand C. 1981 Jun;89(3):193-7. doi: 10.1111/j.1699-0463.1981.tb02685.x.
In order to explore the effect of immunologically-induced nephropathy versus a non-immunological model on development of hypertension, rats with either Heymann nephritis or N,N'-diacetylbenzidine (N,N'-DAB)-induced nephropathy were subjected to DOCA-NaCl treatment. Hypertension developed during DOCA-NaCl treatment in Heymann nephritic rats but not in rats wih N, N'-DAB nephropathy, despite similar degrees of proteinuria and other features of nephrosis. There were no signs of different fluid balance, either. Azotemia did not ensue. Histology and immunohistology showed membranous glomerulonephritis in Heymann nephritic rats whereas glomerular epithelial cell alterations without immune deposits along the glomerular capillary walls were seen in rats with N, N'-DAB nephropathy. The type of renal damage or factors mediating such damage appear to be important determinants for the hypertensive response of Heymann nephritic rats to DOCA-NaCl treatment.
为了探究免疫性肾病与非免疫性模型对高血压发展的影响，对患有海曼肾炎或N，N'-二乙酰联苯胺（N，N'-DAB）诱导性肾病的大鼠进行去氧皮质酮-氯化钠（DOCA-NaCl）处理。在DOCA-NaCl处理期间，海曼肾炎大鼠出现了高血压，但N，N'-DAB肾病大鼠未出现高血压，尽管两者的蛋白尿程度及其他肾病特征相似。两者也均无不同液体平衡的迹象。未出现氮质血症。组织学和免疫组织学检查显示，海曼肾炎大鼠为膜性肾小球肾炎，而N，N'-DAB肾病大鼠的肾小球上皮细胞有改变，但沿肾小球毛细血管壁无免疫沉积物。肾脏损伤的类型或介导此类损伤的因素似乎是海曼肾炎大鼠对DOCA-NaCl处理产生高血压反应的重要决定因素。
