Lochry E A, Riley E P
Neurobehav Toxicol. 1980 Summer;2(2):107-15.
The effects of prenatal alcohol on learning and retention of passive avoidance and discriminated shock escape were examined in offspring of rats who consumed isocaloric liquid diets containing either 35, 17.5 or 0% ethanol derived calories (EDC) or lab chow during pregnancy. Alcohol exposed progeny required more trials to reach criterion during passive avoidance acquisition and had shorter second trail latencies into the shock compartment than did controls. Both these measures were found to be direct functions of prenatal alcohol exposure. No differences between groups were evident during retention testing (1, 3, or 7 days later). During the 25 trial acquisition phase of T-maze escape, alcohol exposed progeny made more errors despite equivalent group performance by the end of training. During retention testing 24 hours later, these offspring again evidenced more errors regardless of whether or not the original contingencies were reversed. Both learning and retention deficits in the T-maze were directly related to the percent EDC consumed by the mother during pregnancy.
研究了孕期食用含35%、17.5%或0%乙醇热量（EDC）的等热量液体饮食或实验室饲料的大鼠后代中，产前酒精对被动回避学习和记忆以及辨别性电击逃避的影响。与对照组相比，暴露于酒精的后代在被动回避习得过程中达到标准需要更多的试验次数，并且进入电击室的第二次试验潜伏期更短。发现这两种测量方法都是产前酒精暴露的直接函数。在记忆测试（1、3或7天后）期间，各组之间没有明显差异。在T迷宫逃避的25次试验习得阶段，尽管训练结束时各组表现相当，但暴露于酒精的后代犯的错误更多。在24小时后的记忆测试中，无论最初的条件是否颠倒，这些后代再次表现出更多的错误。T迷宫中的学习和记忆缺陷都与母亲孕期摄入的EDC百分比直接相关。
