Andrieu J M, Youinou P, Marcelli A
Nouv Presse Med. 1981 Oct 10;10(36):2951-4.
The records of 560 patients treated between 1972 and 1979 were reviewed. Nine patients had both autoimmune haemolytic anemia (AIHA) and Hodgkin's disease; 3 of them belonged to a group of 176 patients in whom a Coomb's test had been systematically performed. The incidence of the association was 1.7%. Five out of 9 patients were in clinical stages III or IV, and 8 had "B" symptoms. All patients were treated with 3 to 6 courses of MOPP followed by irradiation. The survival rate was 56.5% at 89 months. Three patients died, none of AIHA. The discovery of an AIHA at the time of diagnosis or during the course of Hodgkin's disease, the frequent finding of an excess of plasmocytes in Hodgkin's tumours and the negativation of Coomb's test by irradiation of these tumours suggest that the anti-erythrocyte activity originates in the tumoral tissue.
回顾了1972年至1979年间接受治疗的560例患者的记录。9例患者同时患有自身免疫性溶血性贫血(AIHA)和霍奇金病;其中3例属于176例系统性进行库姆斯试验的患者组。这种关联的发生率为1.7%。9例患者中有5例处于临床III期或IV期,8例有“B”症状。所有患者均接受3至6个疗程的MOPP方案治疗,随后进行放疗。89个月时的生存率为56.5%。3例患者死亡,均非死于AIHA。在霍奇金病诊断时或病程中发现AIHA,在霍奇金肿瘤中频繁发现浆细胞增多,以及这些肿瘤经放疗后库姆斯试验转阴,提示抗红细胞活性起源于肿瘤组织。