Christmann D, Bareiss P, Boilletot A, Bergerat J P, Oberling F
Nouv Rev Fr Hematol (1978). 1981;23(3):149-54.
Left ventricular function in 21 patients treated by polychemotherapy including adriamycin (ADM) has been studied by repeated echocardiographic examination. The mean rate of circumferential, the ejection fraction, and the shortening fraction are the most significant data obtained by this investigation. They permit the detection of early damage of left ventricular performance which increases progressively, confirming the dose-dependent nature of the cardiomyopathy. Supervision of patients under ADM is necessary to recognize those who rapidly develop cardiomyopathy. In these cases, treatment interruption may be beneficial. In contrast, patients with little left ventricular damage can be treated by a total dosage of ADM superior to that actually recommended.
对21例接受包括阿霉素（ADM）在内的多药化疗的患者，通过反复超声心动图检查研究了左心室功能。圆周平均速率、射血分数和缩短分数是本次研究获得的最重要数据。它们能够检测到左心室功能的早期损害，且这种损害会逐渐加重，证实了心肌病的剂量依赖性。对接受ADM治疗的患者进行监测，对于识别那些迅速发展为心肌病的患者很有必要。在这些情况下，中断治疗可能有益。相比之下，左心室损害较小的患者可以接受高于实际推荐剂量的ADM总剂量治疗。
