Sledge C B, Noble J
Clin Orthop Relat Res. 1978 Oct(136):111-9.
Kirshner wires were placed either side of the right distal femoral epiphysis and a constant tension device applied a distracting force across the plate in rabbits. Growth increase was measured between the wires and found to be about 150% greater than the concurrent normal growth between 2 control (undistracted) wires on the left; such growth increase can occur in the absence of fracturing. The forces required to do this were between 1/5 and 1/10 of those shown to cause fracturing in vitro. The growth increase was shown to be associated with hyperplasia and hypertrophy of the plate, as well as an increased rate of cell division and sulfated polysaccharide synthesis. This was in turn shown to be associated with an increase in new bone formation.
克氏针置于兔右股骨远端骨骺两侧，并用恒定张力装置在钢板上施加牵张力量。测量克氏针之间的生长增加情况，发现其比左侧两根对照（未牵张）克氏针之间同时期的正常生长大约快150%；这种生长增加可在无骨折的情况下发生。实现这一生长增加所需的力量仅为体外显示会导致骨折的力量的1/5至1/10。结果表明，生长增加与骨骺的增生和肥大有关，同时细胞分裂速率和硫酸化多糖合成增加。进而表明这与新骨形成增加有关。
