尼日利亚（约鲁巴族）人群中磺胺二甲嘧啶的多态性乙酰化

Polymorphic acetylation of sulfamethazine in a Nigerian (Yoruba) population.

Jeyakumar L H, French M R

Xenobiotica. 1981 May;11(5):319-21. doi: 10.3109/00498258109045310.

Abstract

Sulfamehtazine was administered orally to 165 Yoruba subjects (40 mg/kg body wt.). Free and acetylated sulfamethazine were determined in the 6 h urines. 2. The population frequency histogram for percentage of urinary acetylated sulfamethazine was bimodal, although not completely resolved. Slow acetylators constituted 45% of the population studied. 3. This Yoruba population did not differ statistically (P greater than 0.05) in this respect from the two major tribally distinct groups in Nigeria previously investigated.

摘要

给165名约鲁巴受试者口服磺胺二甲嘧啶（40毫克/千克体重）。测定6小时尿液中的游离磺胺二甲嘧啶和乙酰化磺胺二甲嘧啶。2. 尿中乙酰化磺胺二甲嘧啶百分比的群体频率直方图呈双峰型，尽管未完全分开。慢乙酰化者占所研究群体的45%。3. 这一约鲁巴群体在这方面与尼日利亚先前调查的两个主要部落不同的群体相比，在统计学上无差异（P大于0.05）。