Schmähl D
Zentralbl Chir. 1981;106(15):997-1004.
The article discusses possible etiological factors for the carcinogenesis of stomach tumours. Apart from genetic factors, stomach carcinogenesis may be attributed to the exposure of the stomach to carcinogenic substances taken in with the food, such as pyrrolysis products of certain amino acids, N-nitroso compounds or disturbances of the physiological function of the stomach, for example pathological reflux after stomach operations. The frequency of stomach cancer could not be related to occupational exposure. Geographic pathology has shown that people coming from high risk areas (e.g. Japan) adapt to the risk pattern of the host country when they emigrate (e.g. to the United States, where there is only a low risk for stomach cancer). Therefore, it is assumed that several factors play a role in the etiology of stomach cancer.
本文讨论了胃肿瘤致癌的可能病因。除遗传因素外，胃癌的发生可能归因于胃接触食物中摄入的致癌物质，如某些氨基酸的热解产物、N-亚硝基化合物，或胃生理功能的紊乱，例如胃部手术后的病理性反流。胃癌的发病率与职业暴露无关。地理病理学研究表明，来自高风险地区（如日本）的人移民到其他国家（如美国，胃癌风险较低）后，会适应宿主国家的风险模式。因此，人们认为有多种因素在胃癌的病因中起作用。
