手术后胃中的亚硝酸盐和N-亚硝基化合物。
Nitrite and N-nitroso compounds in the operated stomach.
作者信息
Schlag P, Böckler R, Peter M, Herfarth C
出版信息
Scand J Gastroenterol Suppl. 1981;67:63-9.
The concentration of nitrite and N-nitroso compounds was examined in the fasting gastric juice of 44 patients with regard to the known cancer risk of the operated stomach. All patients had been operated for ulcer disease in average 2.5 years previously. Twenty-six age-matched individuals with healthy stomachs figures as a control group. The concentration of nitrite and N-nitroso compounds in the gastric juice of the vagotomized patients (PGV) did not differ from that of the controls. On the other hand, a significant increase of the nitrite concentration was found in gastric juice of patients resected according to Billroth I or II procedure. The fraction of N-nitroso compounds, however, was significantly elevated in comparison to the other gastric juice samples only in the Billroth II-resected stomach. The importance of the increase of nitrite and N-nitroso compounds for the cancer risk inherent to the gastric stump is discussed.
针对已知的残胃癌症风险，检测了44例患者空腹胃液中亚硝酸盐和N-亚硝基化合物的浓度。所有患者平均在2.5年前因溃疡病接受了手术。26名年龄匹配的健康胃部个体作为对照组。迷走神经切断术患者（PGV）胃液中亚硝酸盐和N-亚硝基化合物的浓度与对照组无差异。另一方面，根据毕罗I式或II式手术切除的患者胃液中亚硝酸盐浓度显著升高。然而，仅在毕罗II式切除的胃中，N-亚硝基化合物的比例与其他胃液样本相比显著升高。文中讨论了亚硝酸盐和N-亚硝基化合物增加对残胃癌风险的重要性。
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