Saunders D M, Shuter B, Shearman R P
Contraception. 1978 Nov;18(5):527-34. doi: 10.1016/0010-7824(78)90037-9.
Two combined oral contraceptives, one containing ethinyl estradiol and the other micronized estradiol and estriol, were compared by measuring a variety of endocrine and renal parameters over nine months. Significant changes were observed in plasma renin activity (P.R.A.) on the synthetic estrogen. Much larger changes were observed in the total urinary estrogens on patients taking the "natural" estrogens reflecting the amount of estrogens required to be excreted in the urine.
通过在九个月内测量各种内分泌和肾脏参数，对两种复方口服避孕药进行了比较，一种含有炔雌醇，另一种含有微粉化雌二醇和雌三醇。使用合成雌激素时，血浆肾素活性（P.R.A.）出现了显著变化。服用“天然”雌激素的患者尿中总雌激素的变化要大得多，这反映了尿液中需要排泄的雌激素量。
