Czaplicki S, Gietka J, Sułek K
Cor Vasa. 1978;20(4):249-54.
The authors studied the frequency of coronary heart disease (CHD) and myocardial infarction (MI) in 500 rheumatoid arthritis (RA) patients (116 men and 384 women). Almost 75% RA patients received 15.0-50.0 g of acetylsalicylic acid (ASA) monthly for above 4 years. The authors did not find significant differences in the frequency of CHD risk factors in the group of RA patients and in the Polish population of similar age. The authors noted only 2 cases of MI and 2 cases of CHD in 500 RA patients. All these patients received ASA irregularly and in small doses. The morbidity coefficient analysis showed that MI is 3-times less frequent in RA patients than in the Polish population. The authors suppose that long-term ASA treatment is one of the factors reducing the risk of CHD and MI probably by inhibition of the platelet function.
作者对500例类风湿关节炎（RA）患者（116名男性和384名女性）的冠心病（CHD）和心肌梗死（MI）发生率进行了研究。近75%的RA患者连续4年多每月服用15.0 - 50.0克乙酰水杨酸（ASA）。作者未发现RA患者组与年龄相仿的波兰人群中CHD危险因素发生率存在显著差异。作者在500例RA患者中仅发现2例MI和2例CHD。所有这些患者服用ASA不规律且剂量较小。发病率系数分析表明，RA患者中MI的发生率比波兰人群低3倍。作者推测，长期服用ASA治疗可能是通过抑制血小板功能来降低CHD和MI风险的因素之一。
