氧化刺激下葡萄糖-6-磷酸脱氢酶缺乏的红细胞中的NADP⁺和NADPH
NADP+ and NADPH in glucose-6-phosphate dehydrogenase-deficient erythrocytes under oxidative stimulation.
作者信息
Mareni C, Gaetani G F
出版信息
Biochim Biophys Acta. 1976 Jun 8;430(3):395-8. doi: 10.1016/0005-2728(76)90014-1.
PMID:7294
Abstract
A mild oxidative stimulation of the hexose monophosphate pathway of human glucose-6-phosphate dehydrogenase (EC 1.1.1.49)-deficient erythrocytes (Mediterranean variant) causes a significant drop in NADPH. These results, other than to confirm that glucose-6-phosphate dehydrogenase deficiency is a product deficiency disorder, demonstrate that under oxidative stimulation glutathione reductase may become functionally impaired and GSSG cannot be reduced at a sufficient rate.
摘要
对缺乏葡萄糖-6-磷酸脱氢酶（EC 1.1.1.49）（地中海型变异）的人红细胞的己糖磷酸途径进行轻度氧化刺激，会导致NADPH显著下降。这些结果除了证实葡萄糖-6-磷酸脱氢酶缺乏是一种产物缺乏症外，还表明在氧化刺激下，谷胱甘肽还原酶可能会功能受损，且GSSG无法以足够的速率被还原。
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