[Structural changes in renal tissue in experimental staphylococcal septicopyemia].

The structure of the kidney tissue in mice with staphylococcal septicopyemia due to intraperitoneal introduction of Staph. aureus in various doses was studied. It was found that the level of acute purulent inflammation in the kidney tissue was different depending on the site of the affection: the purulent component predominated in the cortical layer, while the necrotic component in the medullary layer and papillae. The most gross changes in the glomerular filter developed in the presence of a swarm of staphylococci and deposition of electron-dense material in the basal capillary layers. It is noted that the study on the ultrastructural changes in the kidney tissue makes it possible to use them for estimation of highly active antibacterial agents.