Warren D J, Simmonds H A, Gibson T, Naik R B
Arch Dis Child. 1981 Sep;56(9):699-704. doi: 10.1136/adc.56.9.699.
Clinical gout and renal failure was seen in a 9-year-old girl. The family tree showed that 9 out of 11 young females in three generations suffered from hyperuricaemia and normal (n = 1), or impaired (n = 8), renal function. One set of twins occurred in each generation and there is only one living male subject. In members with renal failure there was no improvement in renal function after treatment of hyperuricaemia, and in 2 sisters oral contraceptives appeared to precipitate hypertension. This clinical picture may be more common than is generally realised because of failure to compare blood uric acid values with suitable age- and sex-matched controls. The evidence from this family suggests that hyperuricaemia preceded the development of renal failure.
一名9岁女孩出现了临床痛风和肾衰竭。家族谱系显示，三代中的11名年轻女性中有9名患有高尿酸血症，肾功能正常（1例）或受损（8例）。每一代都有一对双胞胎，在世的男性只有一名。在肾衰竭患者中，高尿酸血症治疗后肾功能没有改善，而且在2名姐妹中，口服避孕药似乎引发了高血压。由于未能将血尿酸值与年龄和性别匹配的合适对照进行比较，这种临床情况可能比普遍意识到的更为常见。这个家族的证据表明，高尿酸血症先于肾衰竭出现。
