Ramos-Damián M, Acosta-Ruiz R, Hernández-Delgado J, Vázquez-Valls E, Gomez-Estrada H
Arch Invest Med (Mex). 1981;12(3):421-30.
It has been reported that a great part of the deleterious effect caused by ionizing radiations is due to oxidative phenomena. The purpose of this work was to investigate if some antioxidants commonly used in the food industry might have a radioprotecting effect. N propyl-galate (NPG), hydroxyanisol-butylated (HAB) and hydroxytoluene-butylated (HTB) were utilized. Forty BALB/C mice that received 600 rads of gamma irradiation from a 60Co emitter died 17.12 +/- 7.82 days after. Thirteen mice that were injected 5 mg of NPG 24 hours and 30 minutes before radiation survived for more than 90 days. This same effect was observed in 13 mice that were also injected with 10 mg NPC and in other 13 that received 10 mg of HAB in the same way. Doses of 5 mg HAB or 5 and 10 mg HTB did not have a radioprotecting effect. When the radiation dose was increased to 800 rads, the radioprotecting effect was absent with any of the NPG, HAB or HTB doses. In protected mice, preservation of higher numbers of hematopoietic cells were observed in the bone marrow together with slight reduction of chromosomal fractures. There results show that antioxidants used in the food industry have a radioprotecting effect that had not been investigated.
据报道，电离辐射造成的很大一部分有害影响是由氧化现象引起的。这项工作的目的是研究食品工业中常用的一些抗氧化剂是否可能具有辐射防护作用。使用了正丙基没食子酸酯（NPG）、丁基化羟基茴香醚（HAB）和丁基化羟基甲苯（HTB）。40只接受来自60Co辐射源600拉德γ射线照射的BALB/C小鼠在照射后17.12±7.82天死亡。13只在辐射前24小时和30分钟注射5毫克NPG的小鼠存活了90多天。在另外13只注射10毫克NPG的小鼠以及另外13只以同样方式注射10毫克HAB的小鼠中也观察到了相同的效果。5毫克HAB或5毫克和10毫克HTB的剂量没有辐射防护作用。当辐射剂量增加到800拉德时，任何剂量的NPG、HAB或HTB都没有辐射防护作用。在受到保护的小鼠中，观察到骨髓中造血细胞数量较多，同时染色体断裂略有减少。这些结果表明，食品工业中使用的抗氧化剂具有尚未被研究的辐射防护作用。
