Wasik M, Skopińska-Rózewska E, Swiecicka G
Arch Immunol Ther Exp (Warsz). 1981;29(3):373-7.
Peripheral blood mononuclear cells, preincubated in ampicillin-containing media, exhibited a markedly decreased antibody-dependent (ADCC) and lectin-induced (LICC) cellular cytotoxicity against L1210 target cells in 9 out of 20 and 7 out of 13 donors, respectively. Additional experiments revealed that ampicillin effect on ADCC is based upon the blocking of the Fcgamma receptor resynthesis, in the case of their damage occurring in the process of cell separation.
在含有氨苄青霉素的培养基中预孵育的外周血单核细胞，在20名供体中有9名、13名供体中有7名分别对L1210靶细胞表现出明显降低的抗体依赖性（ADCC）和凝集素诱导的（LICC）细胞毒性。进一步的实验表明，在细胞分离过程中发生Fcγ受体损伤的情况下，氨苄青霉素对ADCC的影响是基于对Fcγ受体再合成的阻断。
