Axelrod J L, Kochman R S
Arch Ophthalmol. 1981 Nov;99(11):2034-6. doi: 10.1001/archopht.1981.03930020910019.
In an attempt to investigate penetration of cephradine into the primary aqueous humor in man, we administered 500-mg and 1-g doses of cephradine orally to 27 patients about to undergo elective cataract extraction. A mean peak aqueous humor level of 0.87 microgram/mL was obtained at about three hours after the 500-mg dose. The mean peak aqueous humor level after the 1-g dose also occurred at three hours and was 1.99 microgram/mL, with a range from 0.91 to 3.25 microgram/mL. This concentration was greater than the median minimum inhibitory concentration (MIC) of cephradine for Streptococcus pneumoniae, Str pyogenes, and Staphylococcus aureus (when tested in nutrient agar) but was greater than the MIC for 90% of isolates only with Str pyogenes.
为了研究头孢拉定在人体原发性房水中的渗透情况，我们对27例即将接受择期白内障摘除术的患者口服了500毫克和1克剂量的头孢拉定。500毫克剂量给药后约三小时，房水平均峰值水平为0.87微克/毫升。1克剂量给药后的房水平均峰值水平也出现在三小时，为1.99微克/毫升，范围为0.91至3.25微克/毫升。该浓度高于头孢拉定对肺炎链球菌、化脓性链球菌和金黄色葡萄球菌的最低抑菌浓度中位数（在营养琼脂中测试时），但仅对90%的化脓性链球菌分离株高于最低抑菌浓度。
