Torbati D, Lambertsen C J
Brain Res. 1985 Sep 30;344(1):186-90. doi: 10.1016/0006-8993(85)91208-9.
The regional cerebral metabolic rate for glucose (rCMRgl) was autoradiographically measured in conscious rats during 180-210 min of exposure to 3 atmospheres absolute oxygen (ATA O2), 3 ATA N2-O2 normoxia and air at 1 ATA. The exposure time and oxygen pressure in the present study were purposely matched to a parallel project in human subjects. The electrocorticogram (ECoG) was continuously recorded throughout the exposure. According to the ECoG responses, the oxygen-exposed rats fell into two categories: 'resistant' ones, those without changes in ECoG throughout the exposure; and 'sensitive' rats, those with changes in EcoG before or during the rCMRgl measurements. The observed ECoG changes were increased slow wave activity in the delta range, which was in some cases followed by paroxysmal electrical discharges. No changes in rCMRgl were observed in oxygen-exposed 'resistant' rats as compared to air breathing or N2-O2 normoxic rats at 3 ATA. However, in the 'sensitive' rats there were increases in rCMRgl in 8 of the 28 neuroanatomical structures examined as compared to the air breathing and 3 ATA normoxic controls. It is concluded that the increase in rCMRgl are related to the onset of the oxygen-induced preconvulsive changes in ECoG.
在清醒大鼠暴露于3个绝对大气压氧气（ATA O2）、3 ATA氮氧混合气常氧环境和1 ATA空气环境180 - 210分钟期间，通过放射自显影法测量局部脑葡萄糖代谢率（rCMRgl）。本研究中的暴露时间和氧气压力特意与一项针对人类受试者的平行项目相匹配。在整个暴露过程中持续记录脑电图（ECoG）。根据ECoG反应，暴露于氧气的大鼠分为两类：“耐受型”，即在整个暴露过程中ECoG无变化的大鼠；“敏感型”大鼠，即在rCMRgl测量之前或期间ECoG有变化的大鼠。观察到的ECoG变化为δ频段慢波活动增加，在某些情况下随后出现阵发性放电。与在3 ATA呼吸空气或氮氧混合气常氧环境的大鼠相比，暴露于氧气的“耐受型”大鼠的rCMRgl未观察到变化。然而，与呼吸空气和3 ATA常氧对照组相比，在28个检查的神经解剖结构中的8个结构中，“敏感型”大鼠的rCMRgl有所增加。结论是，rCMRgl的增加与氧气诱导的ECoG惊厥前变化的发生有关。
