Strain G M, Van Meter W G, Brockman W H
Epilepsia. 1978 Oct;19(5):493-504. doi: 10.1111/j.1528-1157.1978.tb05176.x.
Generalized EEG seizures were induced in acute, conscious New Zealand albino rabbits with intravenous pentylenetetrazol (PTZ) (10 or 15 mg/kg) or electrical stimulation of the frontal cerebral cortex (ELEC) (50 Hz, 1 msec pulse duration, 2 sec train duration, 4.0-7.6 V). Three anticonvulsant treatments were compared: (1) electrical transhemispheral stimulation of the ansiform or simplex cerebellar lobes (10 Hz, 1.5 msec, 3-4 V), (2) phenobarbital (PB) (25 mg/kg, i.v.), and (3) diphenylhydantoin (DPH) (30 mg/kg, i.v.). After treatment, increments in PTZ dose or stimulation voltage were applied until a seizure was evoked that approximated the original in severity and duration. PTZ seizure thresholds were not elevated by DPH, and electrically induced seizure thresholds were not elevated by cerebellar stimulation (CBL). The four remaining seizure threshold elevations (increase in PTZ dose or stimulation voltage) were significant at a level of 0.025 or greater. Comparison of the elevations of seizure thresholds showed no differences at the 0.01 level of significance. Thus, no differences were seen between elevation of PTZ seizure thresholds by CBL or PB, or elevation of electrically induced seizure thresholds by PB or DPH, when examined on an acute basis.
通过静脉注射戊四氮（PTZ）（10或15毫克/千克）或电刺激新西兰白兔大脑额叶皮层（ELEC）（50赫兹，脉冲持续时间1毫秒，串刺激持续时间2秒，电压4.0 - 7.6伏），在急性清醒的新西兰白化兔中诱发全身性脑电图癫痫发作。比较了三种抗惊厥治疗方法：（1）电刺激小脑袢叶或简单叶的跨半球刺激（10赫兹，1.5毫秒，3 - 4伏），（2）苯巴比妥（PB）（25毫克/千克，静脉注射），以及（3）苯妥英（DPH）（30毫克/千克，静脉注射）。治疗后，增加PTZ剂量或刺激电压，直到诱发一次严重程度和持续时间与原始发作相近的癫痫发作。DPH未提高PTZ癫痫发作阈值，小脑刺激（CBL）未提高电诱发癫痫发作阈值。其余四个癫痫发作阈值升高（PTZ剂量增加或刺激电压增加）在0.025或更高水平上具有显著性。癫痫发作阈值升高的比较在0.01显著性水平上未显示差异。因此，在急性情况下检查时，CBL或PB提高PTZ癫痫发作阈值，以及PB或DPH提高电诱发癫痫发作阈值之间没有差异。
