拉贝洛尔和普萘洛尔对女性性唤起时升压反应的影响。
The effect of labetalol and propranolol on the pressor response to sexual arousal in women.
作者信息
Riley A J, Riley E J
出版信息
Br J Clin Pharmacol. 1981 Sep;12(3):341-4. doi: 10.1111/j.1365-2125.1981.tb01223.x.
Abstract
1 The effect of a single oral dose of labetalol (100 mg), propranolol (80 mg) and placebo on the pressor response to sexual autostimulation has been studied in six female volunteers. 2 Labetalol but not propranolol significantly reduced the increase in blood pressure that occurred at orgasm. 3 The subjective features of the sexual response were assessed by each subject using visual analogue scales. 4 Subjects reported a significant reduction in vaginal lubrication with labetalol compared to both placebo and propranolol. 5 No other effects were noted.
摘要
- 研究了单次口服拉贝洛尔（100毫克）、普萘洛尔（80毫克）和安慰剂对6名女性志愿者性自慰刺激所致升压反应的影响。2. 拉贝洛尔可显著降低性高潮时出现的血压升高，而普萘洛尔则无此作用。3. 每位受试者使用视觉模拟量表评估性反应的主观特征。4. 与安慰剂和普萘洛尔相比，受试者报告服用拉贝洛尔后阴道润滑显著减少。5. 未观察到其他影响。
相似文献
1
The effect of labetalol and propranolol on the pressor response to sexual arousal in women.拉贝洛尔和普萘洛尔对女性性唤起时升压反应的影响。
Br J Clin Pharmacol. 1981 Sep;12(3):341-4. doi: 10.1111/j.1365-2125.1981.tb01223.x.
2
Effects of labetalol and propranolol on histamine-induced bronchoconstriction in normal subjects.拉贝洛尔和普萘洛尔对正常受试者组胺诱导的支气管收缩的影响。
Br J Clin Pharmacol. 1977 Apr;4(2):157-62. doi: 10.1111/j.1365-2125.1977.tb00688.x.
3
Comparative effects of adimolol, labetalol and propranolol on heart rate and blood pressure in man.阿地洛尔、拉贝洛尔和普萘洛尔对人体心率和血压的比较作用。
Br J Clin Pharmacol. 1985 Apr;19(4):405-10. doi: 10.1111/j.1365-2125.1985.tb02662.x.
4
Effects of labetalol and propranolol on blood pressure at rest and during isometric and dynamic exercise.拉贝洛尔和普萘洛尔对静息血压以及等长运动和动态运动期间血压的影响。
Eur J Clin Pharmacol. 1979 Nov;16(5):299-303. doi: 10.1007/BF00605625.
5
Cold pressor test: a comparative study between labetalol and propranolol.
J Assoc Physicians India. 1983 May;31(5):291-2.
6
Renal haemodynamics after chronic treatment with labetalol and propranolol.拉贝洛尔和普萘洛尔长期治疗后的肾血流动力学
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):123S-126S. doi: 10.1111/j.1365-2125.1982.tb01900.x.
7
Comparison of the effects of labetalol and propranolol in healthy men at rest and during exercise.拉贝洛尔与普萘洛尔对健康男性静息及运动状态下影响的比较。
Br J Clin Pharmacol. 1977 Feb;4(1):15-21. doi: 10.1111/j.1365-2125.1977.tb00660.x.
8
Effects of labetalol and propranolol on responses to adrenaline infusion in healthy volunteers.拉贝洛尔和普萘洛尔对健康志愿者肾上腺素输注反应的影响。
Int J Clin Pharmacol Res. 1984;4(1):29-33.
9
Beta blockade by oral propranolol and labetalol.
Clin Pharmacol Ther. 1985 Mar;37(3):277-83. doi: 10.1038/clpt.1985.40.
10
A method for monitoring drug effects on male sexual response: the effect of single dose labetalol.一种监测药物对男性性反应影响的方法：单剂量拉贝洛尔的作用
Br J Clin Pharmacol. 1982 Nov;14(5):695-700. doi: 10.1111/j.1365-2125.1982.tb04959.x.
引用本文的文献
1
Sexual function in women. Do antihypertensive drugs have an impact?
Drug Saf. 1993 Mar;8(3):225-34. doi: 10.2165/00002018-199308030-00004.
2
A method for monitoring drug effects on male sexual response: the effect of single dose labetalol.一种监测药物对男性性反应影响的方法：单剂量拉贝洛尔的作用
Br J Clin Pharmacol. 1982 Nov;14(5):695-700. doi: 10.1111/j.1365-2125.1982.tb04959.x.
3
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.联合α和β受体抑制治疗高血压。
Drugs. 1984;28 Suppl 2:51-68. doi: 10.2165/00003495-198400282-00005.
4
Are blood pressure surges associated with sympathetic stimulation aggravated by beta-adrenoceptor antagonist treatment?β-肾上腺素能受体拮抗剂治疗是否会加重与交感神经刺激相关的血压波动？
Postgrad Med J. 1986 Aug;62(730):731-5. doi: 10.1136/pgmj.62.730.731.
本文引用的文献
1
Blood pressure and respiratory patterns during human coitus.
J Reprod Fertil. 1969 Aug;19(3):405-15. doi: 10.1530/jrf.0.0190405.
2
Reduction in the rise of systolic blood pressure during human coitus by the beta-adrenergic blocking agent, propranolol.
J Reprod Fertil. 1970 Aug;22(3):587-90. doi: 10.1530/jrf.0.0220587.
3
Direct arterial pressure, heart rate and electrocardiogram during human coitus.人类性交过程中的直接动脉压、心率和心电图
J Reprod Fertil. 1974 Oct;40(2):321-31. doi: 10.1530/jrf.0.0400321.
4
Modification of pressor responses induced by 'cold' [proceedings].“寒冷”引起的升压反应的改变[会议记录]
Br J Clin Pharmacol. 1977 Jun;4(3):389P.
5
Plasma noradrenaline and dopamine-beta-hydroxylase during sexual activity.性活动期间的血浆去甲肾上腺素和多巴胺-β-羟化酶
Psychosom Med. 1977 Mar-Apr;39(2):143-8. doi: 10.1097/00006842-197703000-00009.
6
Haemodynamic effects of long-term oral labetalol.长期口服拉贝洛尔的血流动力学效应。
Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):733-6.
7
Plasma noradrenaline and dopamine-beta-hydroxylase during human sexual activity.人类性活动期间的血浆去甲肾上腺素和多巴胺-β-羟化酶
J Psychiatr Res. 1979;15(2):139-45. doi: 10.1016/0022-3956(79)90025-6.
8
Circulatory effects of noradrenaline and adrenaline before and after labetalol.拉贝洛尔用药前后去甲肾上腺素和肾上腺素对循环系统的影响。
Br J Clin Pharmacol. 1979 Apr;7(4):371-8.
9
Adrenoceptor blockade of the circulatory responses to intravenous isoproterenol.静脉注射异丙肾上腺素后循环反应的肾上腺素能受体阻断作用。
Clin Pharmacol Ther. 1978 Sep;24(3):264-73. doi: 10.1002/cpt1978243264.
Zotero 插件