模拟慢性支气管炎个体患者的茶碱反应。
Modelling theophylline response in individual patients with chronic bronchitis.
作者信息
Whiting B, Kelman A W, Barclay J, Addis G J
出版信息
Br J Clin Pharmacol. 1981 Oct;12(4):481-7. doi: 10.1111/j.1365-2125.1981.tb01254.x.
Abstract
1 In six patients with chronic bronchitis, serial changes in both ventilatory function and plasma theophylline concentrations were measured simultaneously for 8 h following 500 mg aminophylline intravenously. 2 Using empirical mathematical models which can integrate this data, parameters were estimated which can express response as a linear function of steady state plasma theophylline levels. 3 Taking Forced Vital Capacity (FVC) as the target response, the mean (+/- s.d.) increase in FVC was 0.06 +/- 0.02 l/micrograms ml-1, starting with pretreatment values in the range 1-21. 4 This analytical approach could be used to determine whether or not a patient with chronic bronchitis could obtain a satisfactory response to theophylline at plasma levels normally encountered in clinical practice.
摘要
- 对6例慢性支气管炎患者，静脉注射500毫克氨茶碱后，同时连续8小时测量通气功能和血浆茶碱浓度的变化。2. 使用能够整合这些数据的经验数学模型，估算出可以将反应表达为稳态血浆茶碱水平线性函数的参数。3. 以用力肺活量（FVC）作为目标反应，FVC的平均（±标准差）增加值为0.06±0.02升/微克毫升-1，起始值在1-21的预处理范围内。4. 这种分析方法可用于确定慢性支气管炎患者在临床实践中通常遇到的血浆水平下对茶碱是否能获得满意反应。
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Modelling theophylline response in individual patients with chronic bronchitis.模拟慢性支气管炎个体患者的茶碱反应。
Br J Clin Pharmacol. 1981 Oct;12(4):481-7. doi: 10.1111/j.1365-2125.1981.tb01254.x.
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