Chevillard C, Barden N, Saavedra J M
Brain Res. 1981 Oct 5;222(1):177-81. doi: 10.1016/0006-8993(81)90955-0.
Ovariectomized rats were given either acute (50 micrograms 12 h or 24 h before sacrifice) or chronic (2 micrograms/day for one month) subcutaneous administration of 17 beta-estradiol. The activities of both type A and type B monoamine oxidase (MAO) in the cerebellum and in the areas A1, A2, and locus coeruleus of the brain stem were determined. The activity of type B MAO was increased by acute and chronic estrogen treatment in the different areas studied, whereas that of type A MAO did not change in the areas A1 and A2 and was decreased in the locus coeruleus and the cerebellum. These results indicate a discriminative action of estrogens on different forms of monoamine oxidase.
对去卵巢大鼠进行皮下注射17β-雌二醇，分为急性给药组（处死前12小时或24小时注射50微克）和慢性给药组（每天注射2微克，持续一个月）。测定了小脑以及脑干的A1、A2区和蓝斑中A型和B型单胺氧化酶（MAO）的活性。在所研究的不同区域，急性和慢性雌激素处理均使B型MAO的活性增加，而A型MAO在A1区和A2区活性未变，在蓝斑和小脑中活性降低。这些结果表明雌激素对不同形式的单胺氧化酶具有差异性作用。
