Di Paolo T, Diagle M, Picard V, Barden N
Exp Brain Res. 1983;51(1):73-6. doi: 10.1007/BF00236804.
Increased serotonin content of the dorsal raphe nucleus and of the substantia nigra were seen following acute (12 h or 24 h) administration of 17 beta-estradiol to ovariectomized rats. No changes were seen in numerous other nuclei of forebrain or hindbrain, and no changes occurred during chronic (1 month) estradiol administration. Changes in the concentration of the major serotonin metabolite, 5-hydroxyindole acetic acid, paralleled those of serotonin. These results show that, under precisely defined conditions and in specific locations only, estradiol can modulate serotonergic neuronal systems.
给去卵巢大鼠急性（12小时或24小时）注射17β-雌二醇后，中缝背核和黑质中的血清素含量增加。前脑或后脑的许多其他核团未见变化，长期（1个月）给予雌二醇期间也未发生变化。主要血清素代谢产物5-羟吲哚乙酸浓度的变化与血清素的变化平行。这些结果表明，仅在精确界定的条件下和特定位置，雌二醇可调节血清素能神经元系统。
