阿片类奖赏作用：下丘脑外侧细胞的独立性

Opiate rewarding action: independence of the cells of the lateral hypothalamus.

作者信息

Britt M D, Wise R A

出版信息

Brain Res. 1981 Oct 5;222(1):213-7. doi: 10.1016/0006-8993(81)90962-8.

Abstract

The posterior lateral hypothalamic area has been suggested as a possible site of action for the reinforcing effects of opiates on the basis of the finding that rats would lever-press for direct microinjections of opiates into this region. The present study reports the effects of kainic acid-induced lateral hypothalamic cell loss on the intravenous self-administration of heroin. Kainic acid injection resulted in marked cellular depletion yet failed to alter heroin self-administration.

摘要

基于大鼠会为将阿片类药物直接微量注射到该区域而按压杠杆这一发现，下丘脑后外侧区被认为是阿片类药物强化作用的一个可能作用位点。本研究报告了海人酸诱导的下丘脑外侧细胞缺失对海洛因静脉自我给药的影响。注射海人酸导致明显的细胞耗竭，但未能改变海洛因的自我给药情况。