Watanabe M
Brain Res. 1981 Nov 23;225(1):51-65. doi: 10.1016/0006-8993(81)90317-6.
Single unit activity was recorded from the prefrontal cortex (principalis, arcuate and inferior convexity areas) of the monkey while the animal was performing a delayed conditional discrimination task. Sequential events of the task were as follows: instructional cue presentation, 1st delay, presentation of two pattern stimuli on left and right windows respectively as a discriminative cue, 2nd delay and choice response to the left or right window. The positive pattern was dependent on the instructional cue. In total, 424 units obtained from two monkeys showed a correlation with some aspects of the task. Of these 424 task-related units, 169 differential between the instructional cues and/or the discriminative cues. The majority of these differential units (n = 123) were found to be related to spatial information processing (related to the side of the response) while 19 differential units were related to non-spatial information processing (related to the color or pattern configuration of the cue). The activity of the remaining 27 differential units was considered to be related to both spatial and non-spatial information processing (related to both the instructional cue and the side of the response) and this type of unit was shown to be involved in conditional information processing. The results indicate that prefrontal units may be related to the meaning of the stimulus independent of its physical properties.
在猴子执行延迟条件辨别任务时，记录其前额叶皮质（主要区、弓状区和下凸面区）的单个神经元活动。该任务的顺序事件如下：呈现指示性线索、第一次延迟、在左右窗口分别呈现两个图案刺激作为辨别线索、第二次延迟以及对左或右窗口的选择反应。阳性图案取决于指示性线索。总共从两只猴子身上获得的424个神经元表现出与任务的某些方面存在相关性。在这424个与任务相关的神经元中，有169个在指示性线索和/或辨别性线索之间存在差异。这些差异神经元中的大多数（n = 123）被发现与空间信息处理有关（与反应的一侧有关），而19个差异神经元与非空间信息处理有关（与线索的颜色或图案配置有关）。其余27个差异神经元的活动被认为与空间和非空间信息处理都有关（与指示性线索和反应的一侧都有关），并且这种类型的神经元被证明参与了条件信息处理。结果表明，前额叶神经元可能与刺激的意义有关，而与其物理特性无关。
