Verdery R B
Can J Biochem. 1981 Aug;59(8):586-92. doi: 10.1139/o81-081.
A model for cholesterol balance between fibroblasts and high density lipoproteins which includes first steps in cholesterol egress is proposed. Kinetic solutions of this model, obtained by digital computer integration of associated differential equations, showed that 15-fold variations in high density lipoprotein levels might be expected to cause less than 8% change in cell cholesterol and twofold variations in lecithin:cholesterol acyltransferase activity might be expected to cause less than 10% change in cell cholesterol. These theoretical calculations are limited by deficiencies in the model. However, they can be used as adjuncts to direct experiment to evaluate the hypothesis that high density lipoproteins and lecithin:cholesterol acyltransferase are involved in cholesterol removal from peripheral cells.
提出了一种成纤维细胞与高密度脂蛋白之间胆固醇平衡的模型，该模型包括胆固醇流出的第一步。通过对相关微分方程进行数字计算机积分得到的该模型动力学解表明，高密度脂蛋白水平15倍的变化预计会导致细胞胆固醇变化小于8%，卵磷脂胆固醇酰基转移酶活性两倍的变化预计会导致细胞胆固醇变化小于10%。这些理论计算受到模型缺陷的限制。然而，它们可作为直接实验的辅助手段，以评估高密度脂蛋白和卵磷脂胆固醇酰基转移酶参与从外周细胞清除胆固醇这一假说。
