Cotlier E
Can J Ophthalmol. 1981 Jul;16(3):113-8.
A method is described for determining the natural progression of senile cataracts in humans and whether certain factors accelerate or decelerate this progression. The method consists in plotting the age of the patient against the degree of opacity of the cataract to find the regression relation. A comparison of cataracts from diabetic and nondiabetic patients revealed that diabetes accelerated senile cataract formation, so that there was a difference of 9.6 years in the age of the two groups with more dense cataracts. Plasma tryptophan levels, which are increased in cataract patients, are lowered by acetylsalicylic acid (ASA). In this study ASA decelerated cataract formation in diabetic and nondiabetic patients. Among the nondiabetic patients cataract formation in a group with osteoarthritis was delayed by an average of 10 years. Deceleration of cataract formation resulting from ASA administration may reduce the need for surgical removal of cataracts.
本文描述了一种确定人类老年性白内障自然进展过程以及某些因素是加速还是减缓这一进展的方法。该方法是将患者年龄与白内障混浊程度进行绘图，以找出回归关系。对糖尿病患者和非糖尿病患者的白内障进行比较发现，糖尿病会加速老年性白内障的形成，因此在白内障较致密的两组患者中，年龄相差9.6岁。白内障患者血浆色氨酸水平升高，而乙酰水杨酸（ASA）可降低该水平。在本研究中，ASA减缓了糖尿病患者和非糖尿病患者白内障的形成。在非糖尿病患者中，患骨关节炎的一组白内障形成平均延迟了10年。服用ASA导致的白内障形成减缓可能会减少白内障手术摘除的需求。
