Villeneuve J P, Pomier G, Huet P M
Can J Physiol Pharmacol. 1981 Jun;59(6):598-603. doi: 10.1139/y81-090.
A method of chronic portal and hepatic vein catheterization in the dog is described. Using this method, hepatic blood flow was measured by an indicator dilution technique and the effect of acute ethanol administration on hepatic blood flow was evaluated in unanesthetized dogs. Intravenous and intragastric ethanol administration (2.0 g.kg-1) resulted in a significant increase in hepatic blood flow. Splanchnic oxygen consumption was also increased following ethanol administration but this effect was offset by the rise in hepatic blood flow and the net result was an increase in hepatic vein oxygen content. These data demonstrate a significant effect of ethanol on hepatic blood flow but suggest that hepatic hypoxia does not occur following acute ethanol administration.
本文描述了一种犬慢性门静脉和肝静脉插管的方法。采用该方法，通过指示剂稀释技术测量肝血流量，并在未麻醉的犬中评估急性给予乙醇对肝血流量的影响。静脉内和胃内给予乙醇（2.0 g·kg-1）导致肝血流量显著增加。给予乙醇后内脏氧耗也增加，但这种影响被肝血流量的增加所抵消，最终结果是肝静脉氧含量增加。这些数据表明乙醇对肝血流量有显著影响，但提示急性给予乙醇后不会发生肝缺氧。
