Naylor J M, Freeman D E, Richardson D, Kronfeld D S
Am J Vet Res. 1985 Jan;46(1):202-8.
A modified catheterization and para-aminohippurate dye dilution technique was used to measure portal and hepatic blood flows in sheep. Blood flows (mean +/- 1SD) for 7 healthy sheep were 1.54 +/- 0.71 L/min and 1.98 +/- 0.75 L/min for portal and hepatic flows, respectively. Blood flow measurement was facilitated when dye injection rates produced blood para-aminohippurate acid concentrations greater than 15 mg/L. Uniform mixing of dye with blood was confirmed in 1 sheep with 2 portal vein catheters. Surgery to place the catheters was facilitated by using a ventral para-costal approach. Blood gas analysis was useful in confirming the placement of the catheters. Useful catheter life in this experiment was 41 days, which was longer than in previous reports. Treating the catheters with an organo-silane preparation, protecting the catheters against dislodgement, and use of a belly bandage to minimize damage to the external parts of the catheter may have prolonged catheter life in this experiment.
采用改良的导管插入术和对氨基马尿酸染料稀释技术来测量绵羊的门静脉和肝血流量。7只健康绵羊的血流量（平均值±1标准差），门静脉血流为1.54±0.71升/分钟，肝血流为1.98±0.75升/分钟。当染料注射速率使血液中对氨基马尿酸浓度大于15毫克/升时，血流量测量变得更容易。在1只安装了2根门静脉导管的绵羊中，证实了染料与血液的均匀混合。采用腹侧肋下进路便于进行放置导管的手术。血气分析有助于确认导管的放置位置。在本实验中导管的有效使用期为41天，这比以前的报道要长。在本实验中，用有机硅烷制剂处理导管、防止导管移位以及使用腹带使导管外部受损最小化，可能延长了导管的使用寿命。
