肾内输注异丙肾上腺素诱导的肾上腺儿茶酚胺分泌的血管紧张素II介导作用。

Angiotensin II mediation of adrenal catecholamine secretion induced by intrarenal isoprenaline infusion.

作者信息

Feuerstein G, Krausz M, Cohen S, Gutman Y, Khosla M C, Bumpus M F

出版信息

Eur J Pharmacol. 1978 Dec 1;52(3-4):375-7. doi: 10.1016/0014-2999(78)90292-3.

Abstract

Isoprenaline infusion into the renal artery of the cat induced an increase in the catecholamine (CA) secretion rate from the adrenal gland. CA release by isoprenaline was preferentially noradrenaline. Intravenous infusion of an angiotensin II (A II) antagonist abolished adrenal CA response to intrarenal isoprenaline injection. It is suggested that intrarenal isoprenaline infusion stimulates renal renin release and A II production which, in turn, stimulates adrenal CA secretion.

摘要

向猫的肾动脉输注异丙肾上腺素可导致肾上腺儿茶酚胺（CA）分泌率增加。异丙肾上腺素释放的CA主要是去甲肾上腺素。静脉输注血管紧张素II（A II）拮抗剂可消除肾上腺对肾内注射异丙肾上腺素的CA反应。提示肾内输注异丙肾上腺素可刺激肾脏肾素释放和A II生成，进而刺激肾上腺CA分泌。