Schraffordt Koops H, Beekhuis H, Oldhoff J, Oosterhuis J W, van der Ploeg E, Vermey A
Cancer. 1981 Nov 1;48(9):1952-7. doi: 10.1002/1097-0142(19811101)48:9<1952::aid-cncr2820480907>3.0.co;2-x.
During the period 1965-1974, 110 patients with stage I malignant melanoma of the extremities were treated by regional isolated perfusion with L-phenylalanine mustard and local excision. In order to study local recurrence and survival, only patients with a primary melanoma Clark Level IV or V and a tumor thickness of more than 1.5 mm were accepted in this study. The determinate survival in patients followed for 5-14 years in 78%; 17% developed positive regional lymph nodes. The local skin recurrence rate was 9% (9 patients); four of these 9 patients simultaneously had distant metastases; the other five patients are alive with NED after retreatment. This series of patients, too, shows that tumor thickness determines the prognosis, both as to local recurrence and as to survival. The mean tumor thickness in the hyperthermically perfused patients was found to clearly exceed that in the normothermically perfused, the mean values being 4.85 mm and 3.87 mm, respectively. Yet local recurrence and regional lymph node metastases proved to be less frequent after hyperthermic than after normothermic perfusion, although the difference was not statistically significant.
1965年至1974年期间，110例肢体I期恶性黑色素瘤患者接受了左旋苯丙氨酸氮芥区域隔离灌注及局部切除治疗。为研究局部复发和生存率，本研究仅纳入原发性黑色素瘤为Clark IV级或V级且肿瘤厚度超过1.5 mm的患者。随访5至14年的患者中，确定生存率为78%；17%出现区域淋巴结阳性。局部皮肤复发率为9%（9例患者）；这9例患者中有4例同时发生远处转移；另外5例患者经再次治疗后无疾病证据存活。该系列患者也表明，肿瘤厚度决定局部复发和生存率的预后。发现热灌注患者的平均肿瘤厚度明显超过常温灌注患者，平均值分别为4.85 mm和3.87 mm。然而，尽管差异无统计学意义，但热灌注后局部复发和区域淋巴结转移的发生率低于常温灌注。
