Kennedy L A, Persaud T V
Exp Pathol (Jena). 1978;15(5):250-9. doi: 10.1016/s0014-4908(78)80065-9.
The use and abuse of drugs has reached epidemic proportions among individuals of child-bearing age. The frequency with which alcohol and pentobarbital are used in our society increases the probability that they will be taken simultaneously. Experiments were designed to investigate the prenatal toxicity of alcoho and pentobarbital interaction in the rat. Pregnant Sprague-Dawley rats were treated intraperitoneally with one of three doses of ethanol (0.56 to 1.4 g/kg) in combination with 5, 15, or 25 mg/kg pentobarbital on days 9 through 12 of gestation. Maternal and fetal toxicities were evaluated and compared with the results of previous studies using the same doses of ethanol and pentobarbital. In pregnant rats treated with combinations of the two drugs, there was no consistent pattern of response. With respect to the offspring, there was no evidence that combinations of ethanol and pentobarbital, at the dose levels used here, had any more deleterious effect on fetal development than either drug acting independently.
药物的使用与滥用在育龄人群中已达到流行程度。在我们的社会中，酒精和戊巴比妥的使用频率增加了它们同时被服用的可能性。设计实验以研究酒精和戊巴比妥相互作用对大鼠的产前毒性。在妊娠第9至12天，给怀孕的斯普拉格-道利大鼠腹腔注射三种剂量的乙醇（0.56至1.4克/千克）之一，分别与5、15或25毫克/千克的戊巴比妥联合使用。评估母体和胎儿毒性，并与之前使用相同剂量乙醇和戊巴比妥的研究结果进行比较。在用两种药物联合治疗的怀孕大鼠中，没有一致的反应模式。关于后代，没有证据表明在此使用的剂量水平下，乙醇和戊巴比妥的联合使用对胎儿发育的有害影响比任何一种药物单独作用更大。
