Shepherd E C, Phillips T D, Joiner G N, Kubena L F, Heidelbaugh N D
J Environ Sci Health B. 1981;16(5 Pt B):557-73. doi: 10.1080/03601238109372279.
Penicillic Acid (PA) and Ochratoxin A (OA) are toxic fungal metabolites that are synergistic in combination. This interaction was investigated using mice which were doses orally as follows: control, none; solvent control, 0.2 ml bicarbonate buffer; PA, 40 mg/kg; OA, 10 mg/kg and combination, 40 mg/kg PA + 10 mg/kg OA. The only significant histopathologic change observed was an acute multifocal toxic tubular nephrosis which appeared most severe in the combination-treated mice killed on day 10. While the combination group had a death rate of 20% (5/25), no deaths occurred in the other treatment groups. The increased death rate and the extensive nephrotoxic findings in the combination group indicate a toxic interaction between OA and PA at sublethal dose levels and is consistent with a renal site of action.
青霉酸（PA）和赭曲霉毒素A（OA）是具有协同作用的有毒真菌代谢产物。使用小鼠对这种相互作用进行了研究，小鼠口服给药如下：对照组，不给药；溶剂对照组，0.2 ml碳酸氢盐缓冲液；PA组，40 mg/kg；OA组，10 mg/kg；联合组，40 mg/kg PA + 10 mg/kg OA。观察到的唯一显著组织病理学变化是急性多灶性中毒性肾小管肾病，在第10天处死的联合治疗小鼠中最为严重。联合组的死亡率为20%（5/25），而其他治疗组未出现死亡。联合组死亡率增加和广泛的肾毒性表现表明，OA和PA在亚致死剂量水平存在毒性相互作用，且与肾脏作用部位一致。
