Tolbert M E, Kamalu J A, Draper G D
J Environ Sci Health B. 1981;16(5 Pt B):575-85. doi: 10.1080/03601238109372280.
The effects of divalent cations on gluconeogenesis in enzymatically isolated rat hepatic parenchymal cells were examined. Cadmium, zinc and copper decreased glucose production from lactate (10 mM). However, manganese at 0.05 to 1.0 mM levels stimulated gluconeogenesis by the cells and reduced the effects of the Cd+2, Zn+2 and Cu+2 on gluconeogenesis. The results indicate that under these in vitro conditions the cations altered an aspect of hepatic function--gluconeogenesis from lactate.
研究了二价阳离子对酶分离的大鼠肝实质细胞糖异生作用的影响。镉、锌和铜降低了由乳酸（10 mM）生成葡萄糖的量。然而，0.05至1.0 mM浓度的锰刺激了细胞的糖异生作用，并减弱了Cd²⁺、Zn²⁺和Cu²⁺对糖异生的影响。结果表明，在这些体外条件下，阳离子改变了肝功能的一个方面——由乳酸生成葡萄糖的过程。
