与巨噬细胞分化抗原Mac-1相关的白细胞表面糖蛋白的分子复杂性
Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.
作者信息
Trowbridge I S, Omary M B
出版信息
J Exp Med. 1981 Nov 1;154(5):1517-24. doi: 10.1084/jem.154.5.1517.
Abstract
Monoclonal antibodies have been obtained that react with the murine leukocyte surface glycoproteins bearing the macrophage differentiation antigen Mac-1. Structural and antigenic analysis shows that related glycoproteins are found on other murine hematopoietic cell types. The data not only illustrate the complexity of cell surface structures that can be detected by means of monoclonal antibodies, but also raise questions as to the functional significance of this family of molecules within the hematopoietic system.
摘要
已获得与带有巨噬细胞分化抗原Mac-1的小鼠白细胞表面糖蛋白发生反应的单克隆抗体。结构和抗原分析表明，在其他小鼠造血细胞类型上也发现了相关的糖蛋白。这些数据不仅说明了借助单克隆抗体可检测到的细胞表面结构的复杂性，还对造血系统内这一家族分子的功能意义提出了疑问。
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