Edson R S, Keys T F
Mayo Clin Proc. 1981 Nov;56(11):683-5.
Twenty-three patients with pulmonary blastomycosis were seen from 1950 to 1975, and long-term follow-up, ranging from 2 to 21 years, was available for 19 patients. Four major treatment groups were identified: surgery alone (eight patients), amphotericin B alone (four patients), surgery and amphotericin B (three patients), and observation (four patients). Six of eight patients who had surgical resection alone were cured; one patient died of cardiopulmonary complications in the immediate postoperative period, and one had a relapse 15 years later. The remaining 11 patients in the three other treatment groups were cured. Although systemic therapy with amphotericin B is clearly indicated for progressive, disseminated, or incompletely resected disease, a period of observation is indicated for nonprogressive or totally resected pulmonary blastomycosis.
1950年至1975年间共诊治了23例肺芽生菌病患者，其中19例患者获得了2至21年的长期随访。确定了四个主要治疗组：单纯手术（8例患者）、单纯两性霉素B（4例患者）、手术加两性霉素B（3例患者）以及观察（4例患者）。仅接受手术切除的8例患者中有6例治愈；1例患者在术后即刻死于心肺并发症，1例在15年后复发。其他三个治疗组中的其余11例患者均治愈。虽然对于进展性、播散性或未完全切除的疾病，明确需要使用两性霉素B进行全身治疗，但对于非进展性或完全切除的肺芽生菌病，建议进行一段时间的观察。
