Mlynarcik D, Denyer S P, Hugo W B
Microbios. 1981;30(119):27-35.
Aspects of the mode of action of three antibacterial agents, N,N'-bis (dodecyldimethyl)-1,2-ethane diammonium dibromide (BDED), 2-piperidinoethyl-4-heptyloxyphenylcarbamate hydrochloride (XXI) and 1-dodecylpiperidine N-oxide (DPNO) against Staphylococcus aureus have been examined. Their ability to modify respiration, proton translocation, potassium leakage and ATP synthesis are reported. In all cases there was a striking correspondence between the minimum inhibitory concentration and the dose level which completely prevented ATP synthesis. It is suggested that for these three chemically distinct molecules, bacteriostasis can be equated to a loss of the cell's ability to synthesize ATP, which, in turn, may stem from an uncoupling of oxidative phosphorylation.
对三种抗菌剂，即二溴化N,N'-双（十二烷基二甲基）-1,2-乙二铵（BDED）、盐酸2-哌啶基乙基-4-庚氧基苯基氨基甲酸酯（XXI）和1-十二烷基哌啶N-氧化物（DPNO）对金黄色葡萄球菌的作用方式进行了研究。报道了它们改变呼吸作用、质子转运、钾离子泄漏和ATP合成的能力。在所有情况下，最低抑菌浓度与完全阻止ATP合成的剂量水平之间存在显著对应关系。有人提出，对于这三种化学结构不同的分子，抑菌作用可等同于细胞合成ATP能力的丧失，而这反过来可能源于氧化磷酸化的解偶联。
