一些5-取代尿嘧啶衍生物的合成与性质
The synthesis and properties of some 5-substituted uracil derivatives.
作者信息
Walker R T, Jones A S, Rahim S G, Serafinowski P, De Clercq E
出版信息
Nucleic Acids Symp Ser. 1981(9):21-4.
PMID:7301597
Abstract
The problems encountered in the synthesis of 5-vinyl-2'-deoxyuridine are outlined and the synthesis of 5-bromoethynyl-2'-deoxyuridine described. E-5-(2-Bromovinyl)-2'-deoxyuridine is the most potent and specific agent against some herpes viruses yet discovered; we have now synthesised the Z-isomer and this appears to be essentially biologically inert.
摘要
概述了5-乙烯基-2'-脱氧尿苷合成过程中遇到的问题，并描述了5-溴乙炔基-2'-脱氧尿苷的合成。E-5-(2-溴乙烯基)-2'-脱氧尿苷是目前发现的对某些疱疹病毒最有效且最具特异性的药物；我们现已合成了Z-异构体，而它似乎基本没有生物活性。
Zotero 插件