Soverchia G, Perri P F
Pediatr Med Chir. 1981 Jan-Feb;3(1):97-9.
Two cases of fetal malformation of a limb are described. The mothers of our patients took an antiemetic, Debendox (dicyclomine hydrochloride 10 mg, doxylamine succinate 10 mg, pyridoxine hydrochloride 10 mg), in early pregnancy, five-six weeks after the last menstrual period. The drug was administered during limbs-buds development period which is thought to occur at 43-46 days after conception. The fetal malformation described, are confronted with congenital abnormalities reported by other authors who suspect that, in early pregnancy, Debendox may have teratogenic properties. Nevertheless, prospective studies of gravidas and their offspring have found no evidence to suggest that Debendox is teratogenic in humans.
本文描述了两例肢体胎儿畸形的病例。我们患者的母亲在妊娠早期，即末次月经后五至六周，服用了一种止吐药——多潘立酮（盐酸双环胺10毫克、琥珀酸多西拉敏10毫克、盐酸吡哆醇10毫克）。该药物是在四肢芽发育期间服用的，四肢芽发育期被认为发生在受孕后43 - 46天。所描述的胎儿畸形与其他作者报告的先天性异常情况相关，这些作者怀疑在妊娠早期，多潘立酮可能具有致畸特性。然而，对孕妇及其后代的前瞻性研究未发现任何证据表明多潘立酮对人类有致畸性。
