Effect of surgery and adjuvant chemotherapy on the R3327 MAT-Ly Lu tumor.

The R3327 MAT-Ly Lu is a prostate derived, anaplastic, hormone independent carcinoma. It spreads primarily to regional lymph nodes, followed by lung metastases. Combination therapy with surgery (tumor removal with or without regional lymphadenectomy) and chemotherapy (ICRF-159) was more effective treatment than either one alone. Primary tumor excision plus lymphadenectomy appeared to reduce the number of pulmonary metastases.