Swezey J L, Baldwin B B, Bromel M C
Poult Sci. 1981 Apr;60(4):738-43. doi: 10.3382/ps.0600738.
Turkeys were given oxytetracycline (OTC) as a feed supplement at levels of 0 g, 50 g, and 200 g OTC per ton of feed. After 8, 16, and 18 weeks the birds were sacrificed and bacteria were isolated from heart blood and liver tissue. When these isolates were tested for resistance against eight antibiotics, a direct correlation was observed between the level of supplement and the level of antibiotic resistance in the bacterial isolates. In postmortem studies on the livers from birds consuming both levels of OTC, an increase in the occurrence of lesions was observed. The livers from control birds appeared to have more granulomas.
给火鸡投喂土霉素（OTC）作为饲料添加剂，添加量分别为每吨饲料0克、50克和200克OTC。在8周、16周和18周后，宰杀这些禽类，并从心脏血液和肝脏组织中分离出细菌。当检测这些分离菌对八种抗生素的耐药性时，观察到添加剂水平与细菌分离株中的抗生素耐药水平之间存在直接相关性。在对食用两种OTC水平的禽类肝脏进行的尸检研究中，观察到病变发生率有所增加。对照禽类的肝脏似乎有更多的肉芽肿。
