Van Alstine W G, Dyer D C
Avian Dis. 1985 Apr-Jun;29(2):430-6.
Oxytetracycline hydrochloride (OTC) was delivered by aerosol to healthy 3-week-old turkeys. Trachea, lung, and plasma were evaluated for OTC levels at 1, 4, 8, 12, 24, and 48 hours after aerosol exposure. In Expt. 1, 15 poults in a modified Horsfall unit were exposed to 1 g OTC/m3 of air using a DeVilbiss ultrasonic nebulizer. In Expt. 2, 25,000 poults in a commercial confinement unit were exposed to 0.075 g of OTC/m3 of air using a Fogmaster fogger. In each case, initially high tracheal and lung OTC concentrations were obtained. OTC levels in the trachea fell to less than 1 microgram/g between 4 and 8 hours postexposure. Plasma OTC levels remained low throughout both experiments. Oxytetracycline was still detectable in room air 60 min after aerosol exposure and before ventilation was restored. This method of administration may have promise for use in respiratory infections, but additional studies are needed to further define the use of aerosol therapy in poultry production units.
将盐酸土霉素（OTC）以气雾剂形式给予健康的3周龄火鸡。在气雾剂暴露后1、4、8、12、24和48小时，对气管、肺和血浆中的OTC水平进行评估。在实验1中，使用德维比斯超声雾化器，在改良的霍斯福尔装置中，让15只雏禽暴露于1克OTC/立方米的空气中。在实验2中，使用福格马斯特喷雾器，在商业饲养单元中，让25000只雏禽暴露于0.075克OTC/立方米的空气中。在每种情况下，最初都获得了较高的气管和肺OTC浓度。暴露后4至8小时，气管中的OTC水平降至低于1微克/克。在两个实验中，血浆中的OTC水平始终较低。在气雾剂暴露后60分钟且通风恢复之前，仍可在室内空气中检测到土霉素。这种给药方法可能有望用于呼吸道感染，但需要进一步研究以进一步确定气雾剂疗法在禽类生产单元中的应用。
