Tabakova S, Khinkova L
Probl Khig. 1981;6:21-6.
The effect of prenatal carbon disulphide exposure with a concentration 10 and 0.33 mg/m3 is studied (MAC for a working zone and atmospheric air resp.) upon the behavioural and neurofunctional development of the generation. A neurotoxicological screening was employed for the assessment of the early postnatal development. It was established that carbon disulphide with a MAC level of the working zone, disturbed the postnatal development without inducing congenital malformations, inducing buit sensory, neurofunctional and behavioural deviations. The results stress upon the high sensitivity of the central nervous system of the growing fetus to carbon disulphide and confirm the expedience of the utilization of neurobehavioural testing as a sensitive method for detecting of sequelae of the effect of prenatal stress with low intensity.
研究了孕期暴露于浓度分别为10毫克/立方米和0.33毫克/立方米的二硫化碳(工作区和大气呼吸的MAC)对子代行为和神经功能发育的影响。采用神经毒理学筛查来评估出生后早期发育。结果表明,工作区MAC水平的二硫化碳干扰了出生后发育,但未诱发先天性畸形,而是引发了感觉、神经功能和行为偏差。这些结果强调了发育中胎儿的中枢神经系统对二硫化碳高度敏感,并证实了将神经行为测试作为检测低强度产前应激影响后遗症的敏感方法的合理性。