在灵长类动物中，局灶性脑内注射脑啡肽后未出现癫痫发作活动。

Absence of seizure activity following focal cerebral injection of enkephalins in a primate.

作者信息

Meldrum B S, Menini C, Naquet R, Riche D, Silva-Comte C

出版信息

Regul Pept. 1981 Nov;2(6):383-90. doi: 10.1016/0167-0115(81)90020-3.

Abstract

Baboons (Papio papio) with photosensitive have been chronically prepared with guide cannulae and deep electrodes to study the effects of focal injections of opioids. In the hippocampus, amygdala and thalamus (centre median) 50--100 micrograms morphine, 20--100 micrograms Met-enkephalin or 2--10 micrograms FK 33,824 do not induce local or general electrographic or motor signs of epilepsy. The acute epileptogenic effect of morphine and enkephalins observed in rats is not a general phenomenon whereas the anticonvulsant action of opioids acting on mu-receptors is seen in rodents and primates.

摘要

已对患有光敏性疾病的狒狒（巴氏狒狒）长期植入引导套管和深度电极，以研究局部注射阿片类药物的效果。在海马体、杏仁核和丘脑（中央中核）中，注射50 - 100微克吗啡、20 - 100微克甲硫氨酸脑啡肽或2 - 10微克FK 33,824不会诱发局部或全身性的脑电图或癫痫运动体征。在大鼠中观察到的吗啡和脑啡肽的急性致癫痫作用并非普遍现象，而作用于μ受体的阿片类药物的抗惊厥作用在啮齿动物和灵长类动物中均可见。