Bianchi A L, St John W M
Respir Physiol. 1981 Aug;45(2):167-83. doi: 10.1016/0034-5687(81)90058-x.
Our purpose was to determine if any medullary respiratory neurons have axonal projections to the rostral pons. In decerebrate, vagotomized, paralyzed and ventilated cats, we monitored efferent phrenic nerve activity and activities of single respiratory and non-respiratory neurons in the regions of the dorsal (DRN) and ventral (VRN) medullary respiratory nuclei. Neurons were classified as bulbospinal, vagal or bulbopontile if stimulation of the spinal cord, vagus nerve or pons elicited antidromic action potentials. If no such action potentials were elicited, the neurons were designated as 'not antidromically activated'. Approximately ten percent of respiratory neurons in both the DRN and VRN were bulbopontile. The great majority of these exhibited tonic or phasic phase-spanning patterns of activity. Effective stimulation loci in pons extended from the area of the trigeminal motor nuclei to the Kolliker-Fuse and parabrachial nuclei. At these same loci, antidromic action potentials were also elicited for some non-respiratory medullary neurons. The possible role of bulbopontile respiratory neurons in the control of automatic ventilatory activity is discussed.
我们的目的是确定是否有任何延髓呼吸神经元具有轴突投射至脑桥前部。在去大脑、切断迷走神经、麻痹并通气的猫中，我们监测了膈神经传出活动以及延髓背侧（DRN）和腹侧（VRN）呼吸核区域单个呼吸和非呼吸神经元的活动。如果刺激脊髓、迷走神经或脑桥引发逆向动作电位，则将神经元分类为延髓脊髓型、迷走神经型或延髓脑桥型。如果未引发此类动作电位，则将神经元指定为“未被逆向激活”。DRN和VRN中约10%的呼吸神经元为延髓脑桥型。其中绝大多数表现出紧张性或阶段性跨相活动模式。脑桥中的有效刺激位点从三叉神经运动核区域延伸至 Kölliker-Fuse核和臂旁核。在这些相同位点，一些非呼吸性延髓神经元也引发了逆向动作电位。本文讨论了延髓脑桥型呼吸神经元在自动通气活动控制中的可能作用。
