Lavie P, Halperin E, Zomer J, Alroy G
Sleep. 1981 Sep;4(3):279-82. doi: 10.1093/sleep/4.3.279.
Systematic trends in the length of apneas were investigated in 8 sleep apnea patients, all of whom had more than 200 apneas per night. Regression analysis performed on the length of apneas by thirds of the night revealed significant linear trends for apneas in sleep stage 2, and for apneas in all sleep stages pooled together. There were no significant trends in the index of apnea density. We suggest that the across-night lengthening of apneas reflects a progressive increase in the arousal threshold, either by a compensatory deepening of sleep or by progressive changes in respiratory chemoreceptor sensitivity. The lack of significant trends in rapid eye movement (REM) sleep supports the conclusion that apnea termination in REM sleep is mediated by a different mechanism than in non-REM sleep.
对8名睡眠呼吸暂停患者的呼吸暂停时长的系统性趋势进行了研究，所有患者每晚的呼吸暂停次数均超过200次。通过将夜间时间三等分对呼吸暂停时长进行回归分析，结果显示在睡眠第二阶段以及所有睡眠阶段汇总后的呼吸暂停存在显著的线性趋势。呼吸暂停密度指数没有显著趋势。我们认为，呼吸暂停的夜间时长延长反映了觉醒阈值的逐渐升高，这可能是由于睡眠的代偿性加深，或者是呼吸化学感受器敏感性的逐渐变化。快速眼动（REM）睡眠中缺乏显著趋势支持了这样的结论，即REM睡眠中的呼吸暂停终止是由与非REM睡眠不同的机制介导的。
