关于囊性纤维化因子（CFF）及其对黏液纤毛功能的潜在影响。
On cystic fibrosis factor (CFF) and its proposed influence on mucociliary function.
作者信息
Tegner H, Toremalm N G
出版信息
Rhinology. 1981 Sep;19(3):115-20.
Cystic fibrosis is a systemic disease where symptoms from the respiratory tract are important. The frequent infections in paranasal sinuses as well as in the lower respiratory tract are related to the occurrence of thick, viscous secretions. Spock et al. (1967) described an abnormal serum factor in patients with cystic fibrosis. This cystic fibrosis factor has been associated with dyskinetic ciliary motion induced by serum and cell culture media from patients with cystic fibrosis. In this study a sensitive method for photoelectric recording of the mucociliary function was used to examine the effect of sera, cell culture media and bronchial lavage fluids from patients with cystic fibrosis. No sign of decreased mucociliary activity was found. Electron microscopy showed morphologically normal cilia.
囊性纤维化是一种全身性疾病，呼吸道症状较为重要。鼻旁窦以及下呼吸道频繁感染与浓稠、粘性分泌物的产生有关。斯波克等人（1967年）描述了囊性纤维化患者存在一种异常血清因子。这种囊性纤维化因子与来自囊性纤维化患者的血清和细胞培养基所诱导的纤毛运动障碍有关。在本研究中，采用了一种用于光电记录黏液纤毛功能的灵敏方法，以检测囊性纤维化患者的血清、细胞培养基和支气管灌洗液的作用。未发现黏液纤毛活性降低的迹象。电子显微镜检查显示纤毛形态正常。
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