Honegger H, Anderson N, Hewitt L A, Tullis J L
Thromb Haemost. 1981 Aug 28;46(2):500-3.
Variations of antithrombin III were studied in a non-randomized population of consecutive cancer cases admitted to a referral hospital. Differences between functional and immunologic assay were observed. Decreases were observed in both assays when compared to a population of hospitalized controls. Patients with cancer of the colon, ovary and prostate showed a deficiency of antithrombin III more frequently than other common tumors. When all tumor cases were subdivided into those in remission compared to those with metastases, a significant decrease in antithrombin III also could be shown. Metastases to the liver were strikingly common in cancer patients with decreased antithrombin III. In these patients, the decrease in antithrombin III could be statistically correlated with reduction in serum albumin.
在一家转诊医院收治的连续癌症病例的非随机人群中研究了抗凝血酶III的变异情况。观察到功能测定和免疫测定之间存在差异。与住院对照人群相比，两种测定中均观察到抗凝血酶III水平下降。结肠癌、卵巢癌和前列腺癌患者比其他常见肿瘤患者更频繁地出现抗凝血酶III缺乏。当将所有肿瘤病例分为缓解期病例和转移病例时，也可显示抗凝血酶III显著下降。抗凝血酶III降低的癌症患者中肝转移极为常见。在这些患者中，抗凝血酶III的降低与血清白蛋白的降低在统计学上相关。
