Ishikawa H, Fukuhara M, Suda K, Murai T, Hashimoto K, Boudene C
Toxicol Eur Res. 1981 Jul;3(4):197-200.
The effect of hepatectomy on the hepatotoxic effect of halogenated hydrocarbons was studied. Male rats received oral administration of chloroform of carbon tetrachloride at a single dose of 500 mg/kg, 3 days prior to or after the partial hepatectomy. The hepatotoxic effect of the toxins was modified in a different manner according to the time of the hepatectomy. In the animals hepatectomized 3 days after the hepatotoxins administration, histological changes of the liver were similar to those of the non-hepatectomized rats, except with an increase in the activity of GOT and GPT. Contrary, in the animals hepatectomized 3 days prior to the hepatotoxins administration, the toxic effect of the chemicals was less enhanced than in the non-hepatectomized animals.
研究了肝切除术对卤代烃肝毒性作用的影响。雄性大鼠在部分肝切除术前或术后3天，以500mg/kg的单次剂量口服给予氯仿或四氯化碳。根据肝切除术的时间不同，毒素的肝毒性作用以不同方式改变。在给予肝毒素3天后进行肝切除的动物中，肝脏的组织学变化与未进行肝切除的大鼠相似，只是谷草转氨酶（GOT）和谷丙转氨酶（GPT）的活性有所增加。相反，在给予肝毒素前3天进行肝切除的动物中，化学物质的毒性作用比未进行肝切除的动物增强得更少。
